- Natural product: Cannabis (Cannabis sativa)
- Associated study: Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells
In Vitro Enzyme Induction Experiment
Induction of CYP1A1 mRNA expression by 50 µM cannabidiol
Induction was detected. Cutoff used —
"The significance of differences between the means of the various groups was evaluated by means of a one-way analysis of variance followed by Bonferroni or Dunnett's post-hoc test."
- CYP1A1 4173297
Cell system HepG2 cell line
Results
Figure 2
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
mRNA expression
1000000 cells/well
Yes
0, 5, 10, 25, 50 µM
6 h
Platinum® SYBR® Green qPCR SuperMix-UDG qPCR (Invitrogen)