ID Natural Product Investigated Study Name Number of Experiments Status
NPDI-pAbidA Green Tea Green Tea Characterization of Material 1
NPDI-LymhiA Goldenseal Goldenseal Characterization of Material 1
NPDI-3xc6sg Kratom Evaluation of In Vitro Absorption, Distribution, Metabolism, and Excretion (ADME) Properties of Mitragynine, 7-Hydroxymitragynine, and Mitraphylline 8
NPDI-BfUWBA Goldenseal The Effects of Berberine on the Pharmacokinetics of Ciclosporin A in Healthy Volunteers 2
NPDI-rHnVZA Green Tea Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. 8
NPDI-iZ0lfA Kratom Evaluation of the Effects of Mitragyna speciosa Alkaloid Extract on Cytochrome P450 Enzymes Using a High Throughput Assay 4
NPDI-_SWDEw Cannabis L. Pharmacological Effects of Cannabinoids on the Caco-2 Cell Culture Model of Intestinal Permeability 2
NPDI-_nacEg Goldenseal An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents 25
NPDI-1nRZnw Goldenseal An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures 1
NPDI-DKPWjw Cannabis L. A phase I study to assess the effect of food on the single dose bioavailability of the THC/CBD oromucosal spray 6
NPDI-B2Lw-w Goldenseal An ex vivo approach to botanical-drug interactions: A proof of concept study 5
NPDI-X6WuUQ Cannabis L. Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity. 15
NPDI-FenBRg Cannabis L. Drug Approval Package: Epidiolex (Cannabidiol) 14
NPDI-wwknDw Goldenseal Differential inhibition of CYP1-catalyzed regioselective hydroxylation of estradiol by berberine and its oxidative metabolites 2
NPDI-XPQ8lg Cannabis L. Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids 8
NPDI-X8i2rQ Green Tea Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes 12
NPDI-RMAz2Q Cannabis L. The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. 6
NPDI-PmWSTA Cannabis L. Cannabidiol Is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19 18
NPDI-bj602A Green Tea Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein 18
NPDI-wXPbVA Green Tea Plasma pharmacokinetics of catechin metabolite 4'-O-Me-EGC in healthy humans 1
NPDI-iw5NFA Goldenseal The Effect of Oxidation on Berberine-Mediated CYP1 Inhibition: Oxidation Behavior and Metabolite-Mediated Inhibition 4
NPDI-O-wCoQ Green Tea Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities 3
NPDI-CjbIUg Green Tea Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 13
NPDI-wdrBKA Goldenseal Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs 6
NPDI-mg3mCg Cannabis L. Influence of cannabidiol on secobarbital effects and plasma kinetics 3
NPDI-2xnPaQ Cannabis L. Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse 6
NPDI-li7_DQ Cannabis L. Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. 12
NPDI-3V9H4g Cannabis L. Medicinal Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel 2
NPDI-8YS2OQ Cannabis L. CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells 2
NPDI-56e_Tw Goldenseal Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study 2
NPDI-aZZelA Green Tea Pharmacokinetics and Safety of Green Tea Polyphenols after Multiple-Dose Administration of Epigallocatechin Gallate and Polyphenon E in Healthy Individuals 1
NPDI-EKeVCQ Goldenseal Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components 12
NPDI-tGISqw Cannabis L. Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes 9
NPDI-fDS50Q Kratom In vitro evaluation of cytochrome P450 induction and the inhibition potential of mitragynine, a stimulant alkaloid 8
NPDI-yD2KTQ Cannabis L. Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study. 3
NPDI-I357eg Cannabis L. The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. 3
NPDI-zXLUrw Green Tea Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation 24
NPDI-OpIPzg Green Tea Effects of repeated green tea catechin administration on human cytochrome P450 activity. 4
NPDI-EGf30Q Goldenseal Effects of Herbal Products and their Constituents on Human Cytochrome P4502E1 Activity 3
NPDI-qiiqjQ Goldenseal Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine 3
NPDI-SUAhzg Cannabis L. Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol 4
NPDI-Qc9Ikg Green Tea Green tea (Camellia sinensis) extract does not alter cytochrome P450 3A4 or 2D6 activity in healthy volunteers. 2
NPDI-kYGOkg Goldenseal Enzyme-inducing effects of berberine on cytochrome P450 1A2 in vitro and in vivo 2
NPDI-2zdQcg Goldenseal In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4 phenotypes 4
NPDI-u-h36w Goldenseal Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2) 2
NPDI-kIMePg Goldenseal Repeated administration of berberine inhibits cytochromes P450 in humans 5
NPDI-WSv1Ww Goldenseal Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1) 3
NPDI-zlwfiw Cannabis L. Structural requirements for potent direct inhibition of human cytochrome P450 1A1 by cannabidiol: role of pentylresorcinol moiety. 5
NPDI-RmNckA Goldenseal Supplementation With Goldenseal (Hydrastis canadensis), but not Kava Kava (Piper methysticum), Inhibits Human CYP3A Activity In Vivo 1
NPDI-lSKaFw Cannabis L. Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes 4
NPDI-PX4G-Q Kratom P-glycoprotein interactions of novel psychoactive substances – Stimulation of ATP consumption and transport across Caco-2 monolayers 1
NPDI-V0ql5A Cannabis L. Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. 6
NPDI-193UdA Cannabis L. The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavir 2
NPDI-QrHT_A Cannabis L. Interaction between naltrexone and oral THC in heavy marijuana smokers 1
NPDI-w1PFPQ Goldenseal Inhibition of P-Glycoprotein by HIV Protease Inhibitors Increases Intracellular Accumulation of Berberine in Murine and Human Macrophages 3
NPDI-6O2hBw Cannabis L. Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). 2
NPDI-wMhoDA Green Tea Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3 4
NPDI-EGZaKw Goldenseal Human MDR1 and MRP1 Recognize Berberine as Their Transport Substrate 1
NPDI-Rl4o7Q Green Tea Blood and Urine Levels of Tea Catechins after Ingestion of Different Amounts of Green Tea by Human Volunteers 3
NPDI-WOzVWg Cannabis L. Interaction between Marihuana and Ethanol: Effects on Psychomotor Performance 3
NPDI-OID6cQ Green Tea Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. 3
NPDI-cyGVpg Goldenseal Time-Dependent Inhibition of CYP2C19 by Isoquinoline Alkaloids: In Vitro and In Silico Analysis 1
NPDI-iZuttw Goldenseal Organic anion-transporting polypeptides contribute to the hepatic uptake of berberine 2
NPDI-UFw-XQ Goldenseal Influence of Goldenseal Root on the Pharmacokinetics of Indinavir 1
NPDI-Hh7GdQ Cannabis L. Safety and pharmacokinetics of oral cannabidiol when administered concomitantly with intravenous fentanyl in humans 1
NPDI-5cRJ6Q Cannabis L. Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana 1
NPDI-bOLDOg Goldenseal Poor permeability and absorption affect the activity of four alkaloids from Coptis 2
NPDI-P-awhA Green Tea Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity. 1
NPDI--p0_rg Goldenseal Tetrandrine Potentiates the Hypoglycemic Efficacy of Berberine by Inhibiting P-Glycoprotein Function 1
NPDI-kdK3MA Goldenseal In Vivo and in Vitro Study on Drug-Drug Interaction of Lovastatin and Berberine from Pharmacokinetic and HepG2 Cell Metabolism Studies 1
NPDI-5ZDmwA Cannabis L. Does olanzapine inhibit the psychomimetic effects of Δ9-tetrahydrocannabinol? 1