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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-bX8XPA Kratom (Mitragyna speciosa) Effects of mitragynine and 7-hydroxymitragynine (the alkaloids of Mitragyna speciosa Korth) on 4-methylumbelliferone glucuronidation in rat and human liver microsomes and recombinant human uridine 5’- diphospho-glucuronosyltransferase isoforms No inhibition of UGT2B7 by ketamine In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • UGT2B7
4-methylumbelliferone 4-methylumbelliferone glucuronide ketamine
NPDI-Ve-SYA Kratom (Mitragyna speciosa) Effects of mitragynine and 7-hydroxymitragynine (the alkaloids of Mitragyna speciosa Korth) on 4-methylumbelliferone glucuronidation in rat and human liver microsomes and recombinant human uridine 5’- diphospho-glucuronosyltransferase isoforms No inhibition of UGT1A1 by ketamine In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • UGT1A1
4-methylumbelliferone 4-methylumbelliferone glucuronide ketamine
NPDI-ipamgg Kratom (Mitragyna speciosa) Effects of mitragynine and 7-hydroxymitragynine (the alkaloids of Mitragyna speciosa Korth) on 4-methylumbelliferone glucuronidation in rat and human liver microsomes and recombinant human uridine 5’- diphospho-glucuronosyltransferase isoforms No inhibition of UGT in human liver microsomes by ketamine In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • UGT
4-methylumbelliferone 4-methylumbelliferone glucuronide ketamine

Compound information from external resources

Resource Identifier
Google search YQEZLKZALYSWHR-UHFFFAOYSA-N